|
KMID : 0360220170580030296
|
|
Journal of the Korean Ophthalmological Society
2017 Volume.58 No. 3 p.296 ~ p.304
|
|
|
Comparison of Choroidal Thickness Change between Ranibizumab and Aflibercept in Age-related Macular Degeneration: Six Month Results
|
|
Kim Im-Gyu
Kim Yong-Il
Kim Jin-Seon
Lee Jung-Ho
Lee Kyoo-Won
Kang Hyun-Gu
|
|
|
Abstract
|
|
|
Purpose: To compare the changes in subfoveal choroidal thickness between intravitreal aflibercept and ranibizumab injection in wet age-related macular degeneration (AMD).
Methods: Fifty patients with wet AMD patients who were treated with aflibercpet or ranibizumab were evaluated retrospectively. All patients were treated with pro re nata after 3 consecutive monthly injections and were followed up for at least 6 months. We measured subfoveal choroidal thickness (SFCT) using enhanced depth imaging spectral-domain optical coherence tomography before the first injection and 1, 2, 3, and 6 months after initial injection.
Results: The SFCT measures before initial injection and 1, 2, 3, and 6 months after initial injection were 244.94 ± 103.77 μm, 219.04 ± 95.89 μm, 208.74 ± 91.03 μm, 203.64 ± 91.35 μm, and 226.98 ± 96.79 μm in the aflibercept group (25 eyes) and 222.68 ± 102.04 μm, 210.23 ± 95.91 μm, 203.66 ± 99.39 μm, 197.27 ± 100.25 μm, and 210.32 ± 111.86 μm in the ranibizumab group (28 eyes). Mean change in SFCT was greater in the aflibercept group at 1 month, 2 months, and 3 months after initial injection (p < 0.05), but there was no significant difference in the mean change in SFCT between the two groups at 6 months after initial injection (p > 0.05).
Conclusions: The decrease in SFCT was greater after aflibercept injection than ranibizumab injection in 3 consecutive months. However, at 6 months after initial injection, the difference in the change in SFCT was not significant.
|
|
|
KEYWORD
|
|
|
Aflibercept, Polypoidal choroidal vasculopathy, Ranibizumab, Subfoveal choroidal thickness, Wet age-related macular degeneration
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|